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Tg(Myh6-KCNQ1_i2)H05Desc
Transgene Detail
Summary
Symbol: Tg(Myh6-KCNQ1_i2)H05Desc
Name: transgene insertion H05, Denis Escande
MGI ID: MGI:5575891
Synonyms: H05
Transgene: Tg(Myh6-KCNQ1_i2)H05Desc  Location: unknown  
Alliance: Tg(Myh6-KCNQ1_i2)H05Desc page
Transgene
origin
Strain of Origin:  FVB
Transgene
description
Transgene Type:    Transgenic (Dominant negative, Humanized sequence, Inserted expressed sequence)
Mutation:    Insertion
 
Tg(Myh6-KCNQ1_i2)H05Desc expresses 1 gene
 
Mutation detailsThe human KCNQ1 isoform 2 is under the control of the mouse alpha-myosin heavy chain promoter (including introns, and three noncoding exons). The stop codon was removed and an 11-amino acid T7 epitope tag was added in frame at the carboxyl terminus of KCNQ1. Isoform 2 does not form functional channels but exerts dominant-negative effects on isoform 1 channels. Western blot analysis confirmed expression. This is the low expressing line. (J:132483)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Disease models
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Expression
In Structures Affected by this Mutation: 3 anatomical structure(s)
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
References
Original:  J:132483 Demolombe S, et al., Transgenic mice overexpressing human KvLQT1 dominant-negative isoform. Part I: Phenotypic characterisation. Cardiovasc Res. 2001 May;50(2):314-27
All:  2 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
06/12/2024
MGI 6.13
The Jackson Laboratory