Tg(Myh6-KCNQ1_i2)H05Desc
Transgene Detail
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Symbol: |
Tg(Myh6-KCNQ1_i2)H05Desc |
Name: |
transgene insertion H05, Denis Escande |
MGI ID: |
MGI:5575891 |
Synonyms: |
H05 |
Transgene: |
Tg(Myh6-KCNQ1_i2)H05Desc Location: unknown
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Alliance: |
Tg(Myh6-KCNQ1_i2)H05Desc page
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Transgene Type: |
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Transgenic (Dominant negative, Humanized sequence, Inserted expressed sequence) |
Mutation: |
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Insertion
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Tg(Myh6-KCNQ1_i2)H05Desc expresses
1 gene
Transgene expresses:
Organism |
Expressed Gene |
Homolog in Mouse |
Note |
human |
KCNQ1 (3784) |
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Mutation details: The human KCNQ1 isoform 2 is under the control of the mouse alpha-myosin heavy chain promoter (including introns, and three noncoding exons). The stop codon was removed and an 11-amino acid T7 epitope tag was added in frame at the carboxyl terminus of KCNQ1. Isoform 2 does not form functional channels but exerts dominant-negative effects on isoform 1 channels. Western blot analysis confirmed expression. This is the low expressing line.
(J:132483)
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View phenotypes and curated references for all genotypes (concatenated display).
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Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available
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Original: |
J:132483 Demolombe S, et al., Transgenic mice overexpressing human KvLQT1 dominant-negative isoform. Part I: Phenotypic characterisation. Cardiovasc Res. 2001 May;50(2):314-27 |
All: |
2 reference(s) |
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