Setd1a^tm1.2Afst
Targeted Allele Detail

Summary

• Symbol: Setd1a^tm1.2Afst
• Name: SET domain containing 1A; targeted mutation 1.2, A Francis Stewart
• MGI ID: MGI:5568941
• Synonyms: Setd1a^FC
• Gene: Setd1a Location: Chr7:127376561-127399294 bp, + strand Genetic Position: Chr7, 69.73 cM
• Alliance: Setd1a^tm1.2Afst page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:208420
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Intragenic deletion
• Mutation details: An FRT-flanked stop cassette containing a reporter, followed by loxP-flanked exon 4 were inserted. Flp-mediated recombination removed the stop codon and Cre mediated recombination excised exon 4, resulting in frameshift. (J:208420)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Setd1a Mutation: 58 strains or lines available

References

• Original: J:208420 Bledau AS, et al., The H3K4 methyltransferase Setd1a is first required at the epiblast stage, whereas Setd1b becomes essential after gastrulation. Development. 2014 Mar;141(5):1022-35
• All: 2 reference(s)