Htra1tm1.1Pfi
Targeted Allele Detail
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Symbol: |
Htra1tm1.1Pfi |
Name: |
HtrA serine peptidase 1; targeted mutation 1.1, Pfizer, Ltd |
MGI ID: |
MGI:5558036 |
Gene: |
Htra1 Location: Chr7:130537933-130587388 bp, + strand Genetic Position: Chr7, 73.2 cM
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Alliance: |
Htra1tm1.1Pfi page
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Increase in bone volume in Htra1tm1.1Pfi/Htra1tm1.1Pfi mice
Show the 1 phenotype image(s) involving this allele.
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Germline Transmission: |
Earliest citation of germline transmission:
J:206395
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Parent Cell Line: |
Not Specified (ES Cell)
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Strain of Origin: |
129S/SvEv
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Allele Type: |
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Targeted (Null/knockout) |
Mutations: |
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Insertion, Intragenic deletion
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Mutation details: A loxP site was inserted upstream of exon 2. A neomycin resistance cassette with a 3' loxP site was inserted downstream of exon 3. Cre-mediated recombination removed the selection cassette and exons 2 and 3.
(J:206395)
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Generation of the Htra1tm1.1Pfi allele |
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View phenotypes and curated references for all genotypes (concatenated display).
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Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available
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Carrying any Htra1 Mutation: |
53 strains or lines available
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Original: |
J:206395 Graham JR, et al., Serine protease HTRA1 antagonizes transforming growth factor-beta signaling by cleaving its receptors and loss of HTRA1 in vivo enhances bone formation. PLoS One. 2013;8(9):e74094 |
All: |
1 reference(s) |
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