Sbno2^tm1.1Aki
Targeted Allele Detail

Summary

• Symbol: Sbno2^tm1.1Aki
• Name: strawberry notch 2; targeted mutation 1.1, Shizuo Akira
• MGI ID: MGI:5551983
• Gene: Sbno2 Location: Chr10:79892826-79941405 bp, - strand Genetic Position: Chr10, 39.72 cM
• Alliance: Sbno2^tm1.1Aki page

Osteopetrotic phenotype of 10 week old Sbno2^tm1.1Aki/Sbno2^tm1.1Aki mice

Show the 2 phenotype image(s) involving this allele.

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:202853
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

Allele Type: Targeted (Null/knockout) Mutations: Insertion, Intragenic deletion Mutation details: A loxP site was inserted upstream of exon 19. A floxed neomycin resistance cassette was inserted downstream of exon 25. Cre-mediated recombination removed exon 19 through 25 and the resistance cassette. RT-PCR confirmed the absence of transcript expression in derived macrophages. (J:202853)

Generation of the Sbno2^tm1.1Aki allele

Expression

In Structures Affected by this Mutation:

3 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Sbno2 Mutation: 56 strains or lines available

References

• Original: J:202853 Maruyama K, et al., Strawberry notch homologue 2 regulates osteoclast fusion by enhancing the expression of DC-STAMP. J Exp Med. 2013 Sep 23;210(10):1947-60
• All: 1 reference(s)