Fus^em1Rkuhn
Endonuclease-mediated Allele Detail

Summary

• Symbol: Fus^em1Rkuhn
• Name: fused in sarcoma; endonuclease-mediated mutation 1, Ralf Kuhn
• MGI ID: MGI:5551889
• Synonyms: Fus^R513G
• Gene: Fus Location: Chr7:127565276-127581204 bp, + strand Genetic Position: Chr7, 69.87 cM
• Alliance: Fus^em1Rkuhn page

Mutation origin

• Strain of Origin: (FVB/N x D2B6F1)F1

Mutation description

• Allele Type: Endonuclease-mediated
• Mutation: Nucleotide substitutions
• Mutation details: TALEN targeting of exon 15 for homologous recombination with a synthetic oligodeoxynucleotide induced a point mutation (C-to-G) that results in the amino acid substitution of arginine with glycine at position 513 (p.R513G). Founder F29 contains the intended point mutation and an additional G-to-A nucleotide substitution within the TALEN-Fus15B targeting sequence. (J:201579)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Fus Mutation: 57 strains or lines available

References

• Original: J:201579 Panda SK, et al., Highly efficient targeted mutagenesis in mice using TALENs. Genetics. 2013 Nov;195(3):703-13
• All: 1 reference(s)