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Transgene Detail
Symbol: Tg(Ccl19-cre)489Biat
Name: transgene insertion 489, Biomodels Austria
MGI ID: MGI:5526991
Synonyms: Ccl19-Cre, transgene insertion 489, Thomas Ruelicke
Transgene: Tg(Ccl19-cre)489Biat  Location: unknown  
Alliance: Tg(Ccl19-cre)489Biat page
Strain of Origin:  C57BL/6N
Transgene Type:    Transgenic (Recombinase)
Mutation:    Insertion
Tg(Ccl19-cre)489Biat expression driven by 1 gene
Mutation detailsA truncated human CD4-IRES-cre sequence with a stop codon was inserted into exon 1 of Ccl19 at the ATG translational start codon in a BAC (RP23446D10). Ccl21b, which is located very close to Ccl19 in the BAC, was disrupted by inserting the human CD8 gene into the first exon. Seven founders were generated and screened by crossing to R26-EYFP reporter mice. 2 of 7 lines had identical stromal-cell specific transgene expression, and founder line 1 was used for all subsequent studies. (J:203158)
 Tissue activity of this recombinase allele
Driver: Ccl19 (mouse)
Summary of all recombinase alleles driven by Ccl19.

In Mice Carrying this Mutation: 1 RNA-Seq or microarray experiment(s)
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Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Original:  J:203158 Chai Q, et al., Maturation of lymph node fibroblastic reticular cells from myofibroblastic precursors is critical for antiviral immunity. Immunity. 2013 May 23;38(5):1013-24
All:  44 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
MGI 6.24
The Jackson Laboratory