Nr3c1^tm1.1Jaci
Targeted Allele Detail

Summary

• Symbol: Nr3c1^tm1.1Jaci
• Name: nuclear receptor subfamily 3, group C, member 1; targeted mutation 1.1, John Cidlowski
• MGI ID: MGI:5526027
• Synonyms: GR^loxP
• Gene: Nr3c1 Location: Chr18:39543598-39652474 bp, - strand Genetic Position: Chr18, 21.09 cM
• Alliance: Nr3c1^tm1.1Jaci page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:201995
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: LoxP sites were inserted in introns 2 and 4, together with a neomycin cassette flanked by Frt sites. Flp recombinase mediated recombination removed the neomycin cassette. (J:201995)

Expression

In Structures Affected by this Mutation:

5 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Nr3c1 Mutation: 34 strains or lines available

References

• Original: J:201995 Oakley RH, et al., Essential role of stress hormone signaling in cardiomyocytes for the prevention of heart disease. Proc Natl Acad Sci U S A. 2013 Oct 15;110(42):17035-40
• All: 8 reference(s)