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Tgm2tm2.1Rmgr
Targeted Allele Detail
Summary
Symbol: Tgm2tm2.1Rmgr
Name: transglutaminase 2, C polypeptide; targeted mutation 2.1, Robert M Graham
MGI ID: MGI:5521582
Synonyms: TG2R579A, TG2R579A deltaneo
Gene: Tgm2  Location: Chr2:157958325-157988312 bp, - strand  Genetic Position: Chr2, 78.72 cM
Alliance: Tgm2tm2.1Rmgr page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:200838
Parent Cell Line:  Bruce 4 (ES Cell)
Strain of Origin:  B6.Cg-Thy1a
Mutation
description
Allele Type:    Targeted (Constitutively active)
Mutations:    Insertion, Nucleotide substitutions
 
Mutation detailsExon 11 was replaced with a modified exon 11 in which nucleotide substitutions (AGA to GCC) result in the amino acid substitution of alanine for arginine at position 579 (R579A). This mutation results in a constitutively active protein. Cre-mediated recombination removed the floxed neomycin resistance cassette inserted downstream of the modified exon 11. (J:200838)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 2 strains available      Cell Lines: 0 lines available
Carrying any Tgm2 Mutation:  49 strains or lines available
References
Original:  J:200838 Iismaa SE, et al., Glucose homeostasis in mice is transglutaminase 2 independent. PLoS One. 2013;8(5):e63346
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
04/16/2024
MGI 6.23
The Jackson Laboratory