Arhgef26^tm1.1Kbur
Targeted Allele Detail

Summary

• Symbol: Arhgef26^tm1.1Kbur
• Name: Rho guanine nucleotide exchange factor 26; targeted mutation 1.1, Keith Burridge
• MGI ID: MGI:5500046
• Gene: Arhgef26 Location: Chr3:62245765-62369642 bp, + strand Genetic Position: Chr3, 29.97 cM
• Alliance: Arhgef26^tm1.1Kbur page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:195919
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

Allele Type: Targeted (Null/knockout) Mutations: Insertion, Intragenic deletion Mutation details: A loxP site was inserted upstream of exon 4. An FRT-flanked neomycin resistance (neo) cassette with a 3' loxP site was inserted downstream of exon 5. Cre-mediated recombination removed exon 4, exon 5 and the neo cassette. Western blot analysis confirmed the absence of protein expression in the liver, lung and brain. (J:195919)

Generation of the Arhgef26^tm1.1Kbur allele

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Arhgef26 Mutation: 49 strains or lines available

References

• Original: J:195919 Samson T, et al., The guanine-nucleotide exchange factor SGEF plays a crucial role in the formation of atherosclerosis. PLoS One. 2013;8(1):e55202
• All: 1 reference(s)