Malat1tm1.2Dlsp
Targeted Allele Detail
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Symbol: |
Malat1tm1.2Dlsp |
Name: |
metastasis associated lung adenocarcinoma transcript 1 (non-coding RNA); targeted mutation 1.2, David L Spector |
MGI ID: |
MGI:5496055 |
Synonyms: |
Malat1 KO |
Gene: |
Malat1 Location: Chr19:5845718-5852700 bp, - strand Genetic Position: Chr19, 4.34 cM
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Alliance: |
Malat1tm1.2Dlsp page
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Allele Type: |
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Targeted (Null/knockout) |
Mutations: |
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Insertion, Intragenic deletion
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Mutation details: An FRT-flanked neomycin resistance cassette with a 3' loxP site was inserted upstream of the coding sequence. An additional loxP site was inserted 1.5 kb downstream of the translation initiation site. Flp-mediated recombination removed the neomycin resistance cassette and left a portion of the coding sequence floxed. Cre-mediated recombination removed the floxed portion of the coding sequence. Northern blot analysis confirmed the absence of transcript expression in the brain and liver.
(J:196017)
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View phenotypes and curated references for all genotypes (concatenated display).
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Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available
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Carrying any Malat1 Mutation: |
8 strains or lines available
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Original: |
J:196017 Zhang B, et al., The lncRNA Malat1 is dispensable for mouse development but its transcription plays a cis-regulatory role in the adult. Cell Rep. 2012 Jul 26;2(1):111-23 |
All: |
6 reference(s) |
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