Rock2^tm2Liao
Targeted Allele Detail

Summary

• Symbol: Rock2^tm2Liao
• Name: Rho-associated coiled-coil containing protein kinase 2; targeted mutation 2, James K Liao
• MGI ID: MGI:5488746
• Gene: Rock2 Location: Chr12:16944896-17037824 bp, + strand Genetic Position: Chr12, 8.04 cM, cytoband A3
• Alliance: Rock2^tm2Liao page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:196433
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129/Sv

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: Two loxP sites flanking exon 3 were introduced and a neomycin resistance gene was inserted between exon 3 and the 3' loxP site. (J:196433)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Rock2 Mutation: 58 strains or lines available

References

• Original: J:196433 Okamoto R, et al., FHL2 prevents cardiac hypertrophy in mice with cardiac-specific deletion of ROCK2. FASEB J. 2013 Apr;27(4):1439-49
• All: 6 reference(s)