Peli1^tm1.1Arte
Targeted Allele Detail

Summary

• Symbol: Peli1^tm1.1Arte
• Name: pellino 1; targeted mutation 1.1, TaconicArtemis
• MGI ID: MGI:5467250
• Synonyms: Pellino1[F397A]
• Gene: Peli1 Location: Chr11:21041291-21100323 bp, + strand Genetic Position: Chr11, 13.81 cM, cytoband A3.2
• Alliance: Peli1^tm1.1Arte page

Enhanced lymphoid cell infiltration in Peli1^tm1.1Arte/Peli1^tm1.1Arte tissues

Show the 1 phenotype image(s) involving this allele.

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:191578
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: C57BL/6N

Mutation description

Allele Type: Targeted (Not Applicable) Mutations: Insertion, Nucleotide substitutions Mutation details: Exon 7 was replaced with a loxP site, modified exon 7 with nulceotide substitutions that result in the amino acid substitution of alanine for phenylalanine at position 397 (F397A), an FRT-flanked puro cassette and a loxP site. Flp-mediated recombination removed the puro cassette and left the modified exon floxed. (J:191578)

Generation of the Peli1^tm1.1Arte allele

Expression

In Structures Affected by this Mutation:

3 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Peli1 Mutation: 31 strains or lines available

References

• Original: J:191578 Enesa K, et al., Pellino1 is required for interferon production by viral double-stranded RNA. J Biol Chem. 2012 Oct 5;287(41):34825-35
• All: 1 reference(s)