Slc6a13^tm1.1Ncd
Targeted Allele Detail

Summary

• Symbol: Slc6a13^tm1.1Ncd
• Name: solute carrier family 6 (neurotransmitter transporter, GABA), member 13; targeted mutation 1.1, NC Danbolt
• MGI ID: MGI:5466694
• Synonyms: GAT2-flox
• Gene: Slc6a13 Location: Chr6:121277247-121314680 bp, + strand Genetic Position: Chr6, 57.22 cM, cytoband F1
• Alliance: Slc6a13^tm1.1Ncd page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:191581
• Parent Cell Line: D1 (ES Cell)
• Strain of Origin: (129S6/SvEvTac x C57BL/6J)F1

Mutation description

Allele Type: Targeted (Conditional ready, No functional change) Mutation: Insertion Mutation details: A loxP site was inserted upstream of exon 5. An FRT-flanked neo cassette with a 3' loxP site was inserted downstream of exon 7. Flp-mediated recombination removed the neo cassette and left exons 5 through 7 floxed. (J:191581)

Generation of the Slc6a13^tm1.1Ncd and Slc6a13^tm1.2Ncd alleles

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Slc6a13 Mutation: 46 strains or lines available

References

• Original: J:191581 Zhou Y, et al., Deletion of the gamma-aminobutyric acid transporter 2 (GAT2 and SLC6A13) gene in mice leads to changes in liver and brain taurine contents. J Biol Chem. 2012 Oct 12;287(42):35733-46
• All: 1 reference(s)