Igs2^{tm1(CAG-rtTA-V10)Naya}
Targeted Allele Detail

Summary

• Symbol: Igs2^{tm1(CAG-rtTA-V10)Naya}
• Name: intergenic site 2; targeted mutation 1, Nihar R Nayak
• MGI ID: MGI:5461210
• Synonyms: Iis2^{tm1(CAG-rtTA-V10)Naya}, Tet-On 3G
• Gene: Igs2 Location: Chr11:3195460-3195497 bp Genetic Position: Chr11, Syntenic
• Alliance: Igs2^{tm1(CAG-rtTA-V10)Naya} page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:190955
• Parent Cell Line: Other (see notes) (ES Cell)
• Strain of Origin: STOCK Igs2^tm3.1Luo/Luo

Mutation description

• Allele Type: Targeted (Transactivator)
• Mutation: Insertion
• Mutation details: Integrase-mediated recombination inserted the third (latest) generation tetracycline-responsive transcriptional activator protein (rtTA-V10 or Tet-On 3G) driven by the ubiquitous CAG promoter into the attP site in Iis2^tm3.1Luo. (J:190955)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Igs2 Mutation: 69 strains or lines available

Notes

This allele was produced in zygotes collected from mice carrying the Igs2^tm3.1Luo allele, which was generated in (129X1/SvJ x 129S1/Sv)F1-Kitl⁺-derived R1 ES cells on a mixed background with 129S1/SvJ, 129X1/SvJ, C57BL/6J, DBA/2J, and FVB/N.

References

• Original: J:190955 Fan X, et al., Transient, inducible, placenta-specific gene expression in mice. Endocrinology. 2012 Nov;153(11):5637-44
• All: 1 reference(s)