Nlrp1b^tm1Bhk
Targeted Allele Detail

Summary

• Symbol: Nlrp1b^tm1Bhk
• Name: NLR family, pyrin domain containing 1B; targeted mutation 1, Beverly H Koller
• MGI ID: MGI:5449888
• Gene: Nlrp1b Location: Chr11:71043928-71121559 bp, - strand Genetic Position: Chr11, 43.23 cM
• Alliance: Nlrp1b^tm1Bhk page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:189777
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129S6/SvEvTac

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• The coding sequence in exon 1, 2 and 3 was replaced with a floxed neo cassette. (J:189777)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Nlrp1b Mutation: 83 strains or lines available

References

• Original: J:189777 Kovarova M, et al., NLRP1-dependent pyroptosis leads to acute lung injury and morbidity in mice. J Immunol. 2012 Aug 15;189(4):2006-16
• All: 8 reference(s)