Mirc32^tm1.1Tyj
Targeted Allele Detail

Summary

• Symbol: Mirc32^tm1.1Tyj
• Name: microRNA cluster 32, including Mir143 and Mir145a; targeted mutation 1.1, Tyler Jacks
• MGI ID: MGI:5447364
• Synonyms: miR-143/145^F, Mir145/Mir143^tm1.1Tyj
• Gene: Mirc32 Location: Chr18:61780896-61782329 bp Genetic Position: Chr18, Syntenic

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:229235
• Parent Cell Line: v6.5 (ES Cell)
• Strain of Origin: (C57BL/6 x 129S4/SvJae)F1

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Insertion
• Mutation details: LoxP sites were introduced approximately 250 bp 5' of Mir145 and 500 bp 3' of Mir143. A FRT-Neo-FRT cassette was also placed 3' of Mir143, just inside the floxed region. Flp-mediated recombination removed the neo cassette. (J:229235)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Mirc32 Mutation: 3 strains or lines available

References

• Original: J:229235 Dimitrova N, et al., Stromal Expression of miR-143/145 Promotes Neoangiogenesis in Lung Cancer Development. Cancer Discov. 2016 Feb;6(2):188-201
• All: 1 reference(s)