Chd7^Coa1
Chemically induced Allele Detail

Summary

• Symbol: Chd7^Coa1
• Name: chromodomain helicase DNA binding protein 7; circling and ocular abnormality 1
• MGI ID: MGI:5436059
• Gene: Chd7 Location: Chr4:8690406-8867659 bp, + strand Genetic Position: Chr4, 3.68 cM
• Alliance: Chd7^Coa1 page

Mutation origin

• Strain of Origin: C57BL/6J

Mutation description

• Allele Type: Chemically induced (ENU)
• Mutation: Single point mutation
• Mutation details: ENU induced an A to T nonsense transition in exon 4. Western blot analysis indicated a lack of protein expression in homozygous embryos. (J:136796, J:187010)
• Inheritance: Dominant

Expression

In Structures Affected by this Mutation:

12 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Chd7 Mutation: 136 strains or lines available

References

• Original: J:187010 Jiang X, et al., The mutation in chd7 causes misexpression of bmp4 and developmental defects in telencephalic midline. Am J Pathol. 2012 Aug;181(2):626-41
• All: 2 reference(s)