Ly75^{tm1.1(HBEGF/EGFP)Ksat}
Targeted Allele Detail

Summary

• Symbol: Ly75^{tm1.1(HBEGF/EGFP)Ksat}
• Name: lymphocyte antigen 75; targeted mutation 1.1, Katsuaki Sato
• MGI ID: MGI:5433322
• Synonyms: Cd205^dtr
• Gene: Ly75 Location: Chr2:60122447-60213617 bp, - strand Genetic Position: Chr2, 34.54 cM
• Alliance: Ly75^{tm1.1(HBEGF/EGFP)Ksat} page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:186395
• Parent Cell Line: Bruce 4 (ES Cell)
• Strain of Origin: B6.Cg-Thy1^a

Mutation description

• Allele Type: Targeted (Inserted expressed sequence, Reporter)
• Mutations: Insertion, Intragenic deletion
• Ly75^{tm1.1(HBEGF/EGFP)Ksat} expresses 1 gene
  Knock-in expresses:
  

  Organism

  Expressed Gene

  Homolog in Mouse

  Note

  human

  HBEGF (1839)

  Hbegf

  (MGI:96070)

• Mutation details: A human diphtheria toxin receptor (HBEGF or DTR) with a 5' IRES was fused to EGFP and inserted into the 3' UTR. A self-excising neo cassette removed itself. (J:186395)

Generation of the Ly75^{tm1.1(HBEGF/EGFP)Ksat} allele

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Ly75 Mutation: 77 strains or lines available

References

• Original: J:186395 Fukaya T, et al., Conditional ablation of CD205+ conventional dendritic cells impacts the regulation of T-cell immunity and homeostasis in vivo. Proc Natl Acad Sci U S A. 2012 Jul 10;109(28):11288-93
• All: 1 reference(s)