Prkra^rep
Chemically induced Allele Detail

Summary

• Symbol: Prkra^rep
• Name: protein kinase, interferon inducible double stranded RNA dependent activator; reduced pinna
• MGI ID: MGI:5430998
• Synonyms: rep, Small ear (Sme)
• Gene: Prkra Location: Chr2:76460242-76478359 bp, - strand Genetic Position: Chr2, 45.07 cM
• Alliance: Prkra^rep page

Prkra^rep/Prkra^rep mice (right) show reduced pinna

Show the 2 phenotype image(s) involving this allele.

Mutation origin

• Strain of Origin: C57BL/6J

Mutation description

Allele Type: Chemically induced (ENU) Mutation: Single point mutation Mutation details: ENU induced a T to C mutation in exon 4 introducing an S130P missense mutation. RT-PCR analysis indicated expression levels in the brain of homozygous mice were similar to wild-type. The mutant protein is unable to bind dsRNA. (J:185991) Inheritance: Recessive

Genetic identification of the Prkra^rep mutation

Expression

In Structures Affected by this Mutation:

5 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Prkra Mutation: 23 strains or lines available

References

• Original: J:185991 Dickerman BK, et al., Missense mutation in the second RNA binding domain reveals a role for Prkra (PACT/RAX) during skull development. PLoS One. 2011;6(12):e28537
• All: 1 reference(s)