Rab38^em2Rkuhn
Endonuclease-mediated Allele Detail

Summary

• Symbol: Rab38^em2Rkuhn
• Name: RAB38, member RAS oncogene family; endonuclease-mediated mutation 2, Ralf Kuhn
• MGI ID: MGI:5430815
• Synonyms: Rab38^IDG-WT
• Gene: Rab38 Location: Chr7:88079481-88140780 bp, + strand Genetic Position: Chr7, 49.19 cM
• Alliance: Rab38^em2Rkuhn page

Mutation origin

• Strain of Origin: (FVB/NCrl x C57BL/6J-Rab38^cht)F1

Mutation description

• Allele Type: Endonuclease-mediated
• Mutation: Nucleotide substitutions
• Mutation details: Zinc finger endonuclease mediated homologous recombination inserted three silent mutations into the wild-type allele (one at the third position of codon 18 and two in the upstream of the two endonuclease binding sites, one of which also abrogates the ApaLI restriction site present in both Rab38^cht and the normal wild-type allele). (J:185512)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Rab38 Mutation: 15 strains or lines available

Notes

Targeted oocytes were derived from an F1 cross using FVB female mice and Rab38^cht male mice.

References

• Original: J:185512 Meyer M, et al., Modeling disease mutations by gene targeting in one-cell mouse embryos. Proc Natl Acad Sci U S A. 2012 Jun 12;109(24):9354-9
• All: 1 reference(s)