Gls^tm2.1Sray
Targeted Allele Detail

Summary

• Symbol: Gls^tm2.1Sray
• Name: glutaminase; targeted mutation 2.1, Stephen Rayport
• MGI ID: MGI:5430235
• Synonyms: floxGLS1, GLS1^lox
• Gene: Gls Location: Chr1:52202607-52272391 bp, - strand Genetic Position: Chr1, 26.86 cM
• Alliance: Gls^tm2.1Sray page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:230564
• Parent Cell Line: W9.5/W95 (ES Cell)
• Strain of Origin: 129S1/Sv-Oca2⁺ Tyr⁺ Kitl⁺

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: The targeting vector was designed to insert a loxP site 16 bp before the start codon in exon 1 and a loxP-flanked neomycin cassette in intron 1. Cre-mediated recombination removed the floxed neo cassette leaving exon 1 floxed. (J:230564)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Gls Mutation: 42 strains or lines available

References

• Original: J:230564 Mingote S, et al., Genetic Pharmacotherapy as an Early CNS Drug Development Strategy: Testing Glutaminase Inhibition for Schizophrenia Treatment in Adult Mice. Front Syst Neurosci. 2015;9:165
• All: 10 reference(s)