Rr91^tm1.1Bkb
Targeted Allele Detail

Summary

• Symbol: Rr91^tm1.1Bkb
• Name: regulatory region 91; targeted mutation 1.1, Barbara K Birshtein
• MGI ID: MGI:5314989
• Synonyms: Igh^tm1.1Bkb
• Gene: Rr91 Location: Chr12:113185086-113188506 bp Genetic Position: Chr12, Syntenic
• Alliance: Rr91^tm1.1Bkb page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:181838
• Parent Cell Line: WW6 (ES Cell)
• Strain of Origin: STOCK 129/Sv and C57BL/6J and SJL

Mutation description

• Allele Type: Targeted (Modified regulatory region)
• Mutation: Intergenic deletion
• Mutation details: A loxP site flanked neomycin resistance gene cassette replaced the Igh-associated DNaseI hypersensitivity sites 5 through 7. Subsequent Cre-mediated recombination removed the neo cassette. (J:181838)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Rr91 Mutation: 0 strains or lines available

References

• Original: J:181838 Volpi SA, et al., Germline Deletion of Igh 3' Regulatory Region Elements hs 5, 6, 7 (hs5-7) Affects B Cell-Specific Regulation, Rearrangement, and Insulation of the Igh Locus. J Immunol. 2012 Mar 15;188(6):2556-66
• All: 2 reference(s)