Tg(Hnf1a-RB1*)XMiu
Transgene Detail

Summary

• Symbol: Tg(Hnf1a-RB1*)XMiu
• Name: transgene insertion X, Naoyuki Miura
• MGI ID: MGI:5312916
• Synonyms: mt-Rb, TGX
• Transgene: Tg(Hnf1a-RB1*)XMiu Location: unknown
• Alliance: Tg(Hnf1a-RB1*)XMiu page

Transgene origin

• Strain of Origin: Not Specified

Transgene description

• Transgene Type: Transgenic (Humanized sequence, Inserted expressed sequence)
• Mutation: Insertion
• Mutation details: The rat Hnf1a enhancer/promoter drives expression of a phosphorylation-resistant mutant human RB1 cDNA. Phosphorylation resistance was created by mutating 12 of 16 consensus phosphorylation sites (8 serines and 4 threonines) to alanines. High levels of transgene expression are detected in the livers of mice in this line. (J:180294)

Tumor Data

List all tumor models in MMHCdb carrying Tg(Hnf1a-RB1*)XMiu

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available

References

• Original: J:180294 Wang B, et al., Liver tumor formation by a mutant retinoblastoma protein in the transgenic mice is caused by an upregulation of c-Myc target genes. Biochem Biophys Res Commun. 2012 Jan 6;417(1):601-6
• All: 1 reference(s)