Th^tm1.1Ich
Targeted Allele Detail

Summary

• Symbol: Th^tm1.1Ich
• Name: tyrosine hydroxylase; targeted mutation 1.1, Hiroshi Ichinose
• MGI ID: MGI:5305343
• Synonyms: Th^fl
• Gene: Th Location: Chr7:142446516-142453732 bp, - strand Genetic Position: Chr7, 88.06 cM
• Alliance: Th^tm1.1Ich page

Dopamine distribution is reduced in the Th^tm1.1Ich/Th^tm1.1Ich striatum

Show the 1 phenotype image(s) involving this allele.

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:178698
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

Allele Type: Targeted (Conditional ready, No functional change) Mutation: Insertion Mutation details: A loxP site was inserted upstream of exon 6. A floxed neo cassette was inserted downstream of exon 9. Cre-mediated recombination removed the neo cassette and left exons 6 through 9 floxed. (J:178698)

Generation of the Th^tm1.1Ich allele

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Th Mutation: 57 strains or lines available

References

• Original: J:178698 Tokuoka H, et al., Compensatory regulation of dopamine after ablation of the tyrosine hydroxylase gene in the nigrostriatal projection. J Biol Chem. 2011 Dec 16;286(50):43549-58
• All: 2 reference(s)