Cldn11^tm1.1Ral
Targeted Allele Detail

Summary

• Symbol: Cldn11^tm1.1Ral
• Name: claudin 11; targeted mutation 1.1, Robert A Lazzarini
• MGI ID: MGI:5304676
• Synonyms: Osprec^-
• Gene: Cldn11 Location: Chr3:31204069-31218473 bp, + strand Genetic Position: Chr3, 15.14 cM
• Alliance: Cldn11^tm1.1Ral page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:180429
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129

Mutation description

• Allele Type: Targeted (Null/knockout, Reporter)
• Mutation: Undefined
• Mutation details: A construct containing a promoterless lacZ gene and a The floxed PGK-neomycin resistance gene of the original targeted allele was removed by cre excision. A promoterless lacZ gene remains in place of exon 1 and a portion of intron 1. Northern blot analysis of extracts from brains and testes showed a lack of transcript in homozygous mutant mice. Western blot analysis confirmed an absence of encoded protein in brain homogenates. Expression of the inserted lacZ gene was under the control of the endogenous promoter. (J:59025, J:180429)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Cldn11 Mutation: 16 strains or lines available

References

• Original: J:180429 Gow A, Transgene-Mediated Rescue of Spermatogenesis in Cldn11-null Mice. Biol Reprod. 2012;86(5):139, 1-11
• All: 3 reference(s)