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Qpctlm1Ingm
Chemically induced Allele Detail
Summary
Symbol: Qpctlm1Ingm
Name: glutaminyl-peptide cyclotransferase-like; mutation 1, Ingenium Pharmaceuticals
MGI ID: MGI:5294355
Synonyms: isoQC-
Gene: Qpctl  Location: Chr7:18874142-18883121 bp, - strand  Genetic Position: Chr7, 9.46 cM, cytoband A2
Alliance: Qpctlm1Ingm page
Mutation
origin
Strain of Origin:  C3HeB/FeJ
Mutation
description
Allele Type:    Chemically induced (ENU)
Mutation:    Single point mutation
 
Mutation detailsENU induced a T to A nucleotide substitution at nucleotide position 442 leading to the introduction of a stop codon in the open reading frame terminating the protein at amino acid 144. (J:100122, J:176575)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Qpctl Mutation:  14 strains or lines available
References
Original:  J:176575 Alexandru A, et al., Selective Hippocampal Neurodegeneration in Transgenic Mice Expressing Small Amounts of Truncated A{beta} Is Induced by Pyroglutamate-A{beta} Formation. J Neurosci. 2011 Sep 7;31(36):12790-12801
All:  2 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
07/02/2024
MGI 6.13
The Jackson Laboratory