Chrna4^tm1.1Tmcg
Targeted Allele Detail

Summary

• Symbol: Chrna4^tm1.1Tmcg
• Name: cholinergic receptor, nicotinic, alpha polypeptide 4; targeted mutation 1.1, Tresa M McGranahan
• MGI ID: MGI:5285618
• Synonyms: alpha4 lox
• Gene: Chrna4 Location: Chr2:180664104-180685339 bp, - strand Genetic Position: Chr2, 103.54 cM
• Alliance: Chrna4^tm1.1Tmcg page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:174505
• Parent Cell Line: CCE/EK.CCE (ES Cell)
• Strain of Origin: 129S/SvEv-Gpi1^c

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: A loxP site was inserted upstream of exon 5. A floxed neo cassette was inserted downstream of exon 5. Cre-mediated recombination removed the neo cassette and left exon 5 floxed. (J:174505)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Chrna4 Mutation: 42 strains or lines available

References

• Original: J:174505 McGranahan TM, et al., alpha4beta2 nicotinic acetylcholine receptors on dopaminergic neurons mediate nicotine reward and anxiety relief. J Neurosci. 2011 Jul 27;31(30):10891-902
• All: 2 reference(s)