Slc4a7^{Tg(Thy1-SNCA)12Mjff}
Transgenic Allele Detail

Summary

• Symbol: Slc4a7^{Tg(Thy1-SNCA)12Mjff}
• Name: solute carrier family 4, sodium bicarbonate cotransporter, member 7; transgene insertion 12, The Michael J Fox Foundation
• MGI ID: MGI:5049859
• Synonyms: mThy1-hSNCA, Tg(Thy1-SNCA)12Youy
• Gene: Slc4a7 Location: Chr14:7669819-7766808 bp, - strand Genetic Position: Chr14, 7.08 cM
• Alliance: Slc4a7^{Tg(Thy1-SNCA)12Mjff} page

Transgene origin

• Strain of Origin: C57BL/6NTac

Transgene description

• Transgene Type: Transgenic (Humanized sequence, Inserted expressed sequence, Null/knockout)
• Mutations: Duplication, Insertion
• Slc4a7^{Tg(Thy1-SNCA)12Mjff} expresses 1 gene
  Transgene expresses:
  

  Organism

  Expressed Gene

  Homolog in Mouse

  Note

  human

  SNCA (6622)

  Snca	(MGI:1277151)

• Mutation details: The transgene contains the human alpha-synuclein (SNCA) gene driven by a mouse thymus cell antigen 1 (Thy-1) promoter. Line 12 inserted into the gene at 14719103-14719104 (Build GRCm38/mm10) resulting in a duplication. The duplication results in a functional knock-out of Slc4a7 in homozygous mice. (J:173668)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Slc4a7 Mutation: 76 strains or lines available

References

• Original: J:173668 Ouyang Y, Direct Data Submission 2011/07/19. MGI Direct Data Submission. 2011
• All: 2 reference(s)