Gbp2b^tm1Tigm
Targeted Allele Detail

Summary

• Symbol: Gbp2b^tm1Tigm
• Name: guanylate binding protein 2b; targeted mutation 1, Texas A&M Institute for Genomic Medicine
• MGI ID: MGI:5013366
• Gene: Gbp2b Location: Chr3:142300608-142324940 bp, + strand Genetic Position: Chr3, 66.69 cM
• Alliance: Gbp2b^tm1Tigm page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:172364
• Parent Cell Line: Lex-2 (ES Cell)
• Strain of Origin: 129S5/SvEvBrd

Mutation description

• Allele Type: Targeted (Null/knockout, Reporter)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Exons 2 through 4 were replaced with a neo/lacZ cassette. Reduced protein expression in IFN-gamma-activated bone marrow macrophages was confirmed by western blot analysis. (J:172364)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Gbp2b Mutation: 47 strains or lines available

References

• Original: J:172364 Kim BH, et al., A family of IFN-gamma-inducible 65-kD GTPases protects against bacterial infection. Science. 2011 May 6;332(6030):717-21
• All: 1 reference(s)