Gt(ROSA)26Sor^{tm2(VEGFB*)Dlam}
Targeted Allele Detail

Summary

• Symbol: Gt(ROSA)26Sor^{tm2(VEGFB*)Dlam}
• Name: gene trap ROSA 26, Philippe Soriano; targeted mutation 2, Diether Lambrechts
• MGI ID: MGI:5009043
• Synonyms: stop^loxVEGF-B¹⁸⁶
• Gene: Gt(ROSA)26Sor Location: Chr6:113044389-113054205 bp, - strand Genetic Position: Chr6, 52.73 cM
• Alliance: Gt(ROSA)26Sor^{tm2(VEGFB*)Dlam} page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:172783
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Conditional ready, Humanized sequence, Inserted expressed sequence)
• Mutation: Insertion
• Gt(ROSA)26Sor^{tm2(VEGFB*)Dlam} expresses 1 gene
  Knock-in expresses:
  

  Organism

  Expressed Gene

  Homolog in Mouse

  Note

  human

  VEGFB (7423)

  Vegfb

  (MGI:106199)

• Mutation details: The human VEGFB isoform 186 sequence was cloned downstream of an in-frame loxP flanked STOP cassette (lox-neo-lox). In the presence of cre recombinase, the STOP cassette is removed and expression of VEGF-B<186> results. (J:172783)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Gt(ROSA)26Sor Mutation: 1046 strains or lines available

References

• Original: J:172783 Dhondt J, et al., Neuronal FLT1 receptor and its selective ligand VEGF-B protect against retrograde degeneration of sensory neurons. FASEB J. 2011 May;25(5):1461-73
• All: 1 reference(s)