Tg(APOE-rtTA*M2,tetO-Rgs16)#Tmw
Transgene Detail

Summary

• Symbol: Tg(APOE-rtTA*M2,tetO-Rgs16)#Tmw
• Name: transgene insertion, Thomas M Wilkie
• MGI ID: MGI:5004809
• Synonyms: TgR16
• Transgene: Tg(APOE-rtTA*M2,tetO-Rgs16)#Tmw Location: unknown
• Alliance: Tg(APOE-rtTA*M2,tetO-Rgs16)#Tmw page

Fatty liver in doxycyline-treated Tg(APOE-rtTA*M2,tetO-Rgs16)#Tmw/0 mice

Show the 1 phenotype image(s) involving this allele.

Transgene origin

• Strain of Origin: C57BL/6 x DBA

Transgene description

• Transgene Type: Transgenic (Inducible, Inserted expressed sequence, Transactivator)
• Mutation: Insertion
• Tg(APOE-rtTA*M2,tetO-Rgs16)#Tmw expresses 1 gene
  Transgene expresses:
  

  Organism	Expressed Gene	Note
  mouse	Rgs16 (MGI:108407)

• Mutation details: A transgene containing the human promoter and gene with its liver control region that drives liver-specific expression of an optimized reverse tetracycline-controlled transactivator (rtTA*M2) in place of exon 3 and a transgene containing the tetracycline responsive element that drives inducible expression of the mouse cDNA with 3 C-terminal myc tags were co-injected. The pound symbol (#) is used when no line is specified and/or lines are pooled. (J:172091)

Schematic of the Tg(APOE-rtTA*M2,tetO-Rgs16)#Tmw transgene

Expression

In Structures Affected by this Mutation:

2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available

References

• Original: J:172091 Pashkov V, et al., Regulator of G Protein Signaling (RGS16) Inhibits Hepatic Fatty Acid Oxidation in a Carbohydrate Response Element-binding Protein (ChREBP)-dependent Manner. J Biol Chem. 2011 Apr 29;286(17):15116-25
• All: 1 reference(s)