Xist^tm5.1Nbd
Targeted Allele Detail

Summary

• Symbol: Xist^tm5.1Nbd
• Name: inactive X specific transcripts; inactive X specific transcripts; targeted mutation 5.1, Neil Brockdorff
• MGI ID: MGI:4950442
• Synonyms: Xist^deltaneo
• Gene: Xist Location: ChrX:102503979-102526839 bp, - strand Genetic Position: ChrX, 46.15 cM, cytoband D
• Alliance: Xist^tm5.1Nbd page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:171502
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Not Applicable)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A floxed neo cassette was inserted into exon 1 in ES cells containing Xist^tm4.1Nbd, which lacks exon 4. Cre-mediated recombination removed the neo cassette. (J:171502)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Xist Mutation: 8 strains or lines available

References

• Original: J:171502 Senner CE, et al., Disruption of a conserved region of Xist exon 1 impairs Xist RNA localisation and X-linked gene silencing during random and imprinted X chromosome inactivation. Development. 2011 Apr;138(8):1541-50
• All: 1 reference(s)