Nlrc5^tm1Aki
Targeted Allele Detail

Summary

• Symbol: Nlrc5^tm1Aki
• Name: NLR family, CARD domain containing 5; targeted mutation 1, Shizuo Akira
• MGI ID: MGI:4939792
• Gene: Nlrc5 Location: Chr8:95160984-95253900 bp, + strand Genetic Position: Chr8, 46.55 cM
• Alliance: Nlrc5^tm1Aki page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:168788
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: 1.5 kb encoding exon 4 was replaced with a neo cassette. The absence of transcript expression was confirmed by RT-PCR analysis on GM-CSF-induced bone marrow dendritic cell extracts. (J:168788)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Nlrc5 Mutation: 66 strains or lines available

References

• Original: J:168788 Kumar H, et al., NLRC5 deficiency does not influence cytokine induction by virus and bacteria infections. J Immunol. 2011 Jan 15;186(2):994-1000
• All: 6 reference(s)