Lepr^m5Btlr
Chemically induced Allele Detail

Summary

• Symbol: Lepr^m5Btlr
• Name: leptin receptor; mutation 5, Bruce Beutler
• MGI ID: MGI:4839995
• Synonyms: db³³³
• Gene: Lepr Location: Chr4:101574601-101672549 bp, + strand Genetic Position: Chr4, 46.96 cM
• Alliance: Lepr^m5Btlr page

Mutation origin

• Strain of Origin: C57BL/6
• Project Collection: Beutler Mutagenetix

Mutation description

• Allele Type: Chemically induced (ENU)
• Mutation: Single point mutation
• ENU induced a T to A transversion results in a tyrosine to stop codon (Y333stop). (J:166105)

Expression

In Structures Affected by this Mutation:

7 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Lepr Mutation: 121 strains or lines available

References

• Original: J:166105 Osborn O, et al., Metabolic characterization of a mouse deficient in all known leptin receptor isoforms. Cell Mol Neurobiol. 2010 Jan;30(1):23-33
• All: 1 reference(s)