Mapk8ip1^tm3.1Rjd
Targeted Allele Detail

Summary

• Symbol: Mapk8ip1^tm3.1Rjd
• Name: mitogen-activated protein kinase 8 interacting protein 1; targeted mutation 3.1, Roger J Davis
• MGI ID: MGI:4829783
• Synonyms: Mapk8ip1^T103A
• Gene: Mapk8ip1 Location: Chr2:92214021-92231608 bp, - strand Genetic Position: Chr2, 50.99 cM, cytoband E1
• Alliance: Mapk8ip1^tm3.1Rjd page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:163808
• Parent Cell Line: TC1/TC-1 (ES Cell)
• Strain of Origin: 129S6/SvEvTac

Mutation description

• Allele Type: Targeted (Not Specified)
• Mutations: Insertion, Nucleotide substitutions
• Mutation details: A targeting construct was made containing exon 3 of the mitogen-activated protein kinase 8 interacting protein 1 (Mapk8ip1 or Jip1) gene. Codon 103 in exon 3 was mutated from a Threonine (ACT) to an Alanine (GCC) (T103A), and a loxP-flanked neomycin (neo) resistance cassette was placed downstream of exon 3. Cre mediated recombination removed the neo cassette. (J:163808)

Expression

In Structures Affected by this Mutation:

3 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Mapk8ip1 Mutation: 33 strains or lines available

References

• Original: J:163808 Morel C, et al., Requirement of JIP1-Mediated c-Jun N-Terminal Kinase Activation for Obesity-Induced Insulin Resistance. Mol Cell Biol. 2010 Oct;30(19):4616-25
• All: 2 reference(s)