Mei4^tm1Bdm
Targeted Allele Detail

Summary

• Symbol: Mei4^tm1Bdm
• Name: meiotic double-stranded break formation protein 4; targeted mutation 1, Bernard de Massy
• MGI ID: MGI:4818799
• Synonyms: Mei4^-
• Gene: Mei4 Location: Chr9:81745723-82088060 bp, + strand Genetic Position: Chr9, 44.72 cM
• Alliance: Mei4^tm1Bdm page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:161203
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129S2/SvPas

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Exon 2 which contains the translation initiation codon and the conserved SSM1 and SSM2 motifs, as well as part of intron 1 and intron 2, was replaced by a floxed neomycin selection cassette. (J:161203)

Expression

In Structures Affected by this Mutation:

8 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Mei4 Mutation: 27 strains or lines available

References

• Original: J:161203 Kumar R, et al., Functional conservation of Mei4 for meiotic DNA double-strand break formation from yeasts to mice. Genes Dev. 2010 Jun 15;24(12):1266-80
• All: 5 reference(s)