Del(17Abcg1-Rrp1b)5Yey
Targeted Allele Detail

Summary

• Symbol: Del(17Abcg1-Rrp1b)5Yey
• Name: deletion, Chr 17, Y Eugene Yu 5
• MGI ID: MGI:4818361
• Synonyms: Del(17)1Yey, Del(17Abcg1-Rrp1b)1Yey, Del5Yey, Df(17)1Yey, Df(Abcg1-Rrp1b)1Yey
• Gene: Del(17Abcg1-Rrp1b)5Yey Location: Chr17:31276672-32281839 bp Genetic Position: Chr17, Syntenic

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:161398
• Parent Cell Line: AB2.2 (ES Cell)
• Strain of Origin: 129S7/SvEvBrd-Hprt1^b-m2

Mutation description

Allele Type: Targeted (Null/knockout) Mutations: Insertion, Intergenic deletion, Intragenic deletion Del(17Abcg1-Rrp1b)5Yey involves 28 genes/genome features (Gm24970, Gm25447, Gm25883 ...) View all Mutation details: Cre mediated chromosomal rearrangement between loxP sites in regions proximal to Abcg1 and distal to Rrp1b resulted in the deletion of the genes, including Abcg1 and Rrp1b, in this approximately 1.1 Mb region that is syntenic with the proximal part of human 21q22.3. (J:161398)

Generation of the Del(17Abcg1-Rrp1b)5Yey deletion

Disease models

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Del(17Abcg1-Rrp1b)5Yey Mutation: 1 strain or line available

References

• Original: J:161398 Yu T, et al., Deficiencies in the region syntenic to human 21q22.3 cause cognitive deficits in mice. Mamm Genome. 2010 Jun;21(5-6):258-67
• All: 1 reference(s)