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Pcsk1ntm1Jep
Targeted Allele Detail
Summary
Symbol: Pcsk1ntm1Jep
Name: proprotein convertase subtilisin/kexin type 1 inhibitor; targeted mutation 1, John E Pintar
MGI ID: MGI:4459814
Gene: Pcsk1n  Location: ChrX:7786061-7790649 bp, + strand  Genetic Position: ChrX, 3.57 cM, cytoband A1.1
Alliance: Pcsk1ntm1Jep page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:161415
Parent Cell Line:  AB2.2 (ES Cell)
Strain of Origin:  129S7/SvEvBrd-Hprt1b-m2
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutation:    Insertion
 
Mutation detailsA neomycin resistance cassette was inserted within intron 1 by homologous recombination. The absence of transcript was confirmed by Northern blot of whole brains from homozygous mutants. (J:161415)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Structures Affected by this Mutation: 1 anatomical structure(s)
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Pcsk1n Mutation:  12 strains or lines available
References
Original:  J:161415 Morgan DJ, et al., The propeptide precursor proSAAS is involved in fetal neuropeptide processing and body weight regulation. J Neurochem. 2010 Jun 1;113(5):1275-84
All:  4 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
07/02/2024
MGI 6.13
The Jackson Laboratory