Prss12^tm1Mits
Targeted Allele Detail

Summary

• Symbol: Prss12^tm1Mits
• Name: serine protease 12 neurotrypsin (motopsin); targeted mutation 1, Shinichi Mitsui
• MGI ID: MGI:4456117
• Synonyms: motopsin KO
• Gene: Prss12 Location: Chr3:123240562-123300246 bp, + strand Genetic Position: Chr3, 54.58 cM, cytoband G3
• Alliance: Prss12^tm1Mits page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:157626
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A PGKneo cassette replaced exon 1 of the gene by homologous recombination. The lack of protein was confirmed by immunohistochemistry on brain tissue. (J:157626)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Prss12 Mutation: 36 strains or lines available

References

• Original: J:157626 Mitsui S, et al., A mental retardation gene, motopsin/neurotrypsin/prss12, modulates hippocampal function and social interaction. Eur J Neurosci. 2009 Dec;30(12):2368-78
• All: 2 reference(s)