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Cyp3a25tm1e(KOMP)Wtsi
Targeted Allele Detail
Summary
Symbol: Cyp3a25tm1e(KOMP)Wtsi
Name: cytochrome P450, family 3, subfamily a, polypeptide 25; targeted mutation 1e, Wellcome Trust Sanger Institute
MGI ID: MGI:4455614
Gene: Cyp3a25  Location: Chr5:145914004-145946428 bp, - strand  Genetic Position: Chr5, 85.17 cM
IMPC: Cyp3a25 gene page
Mutation
origin
Mutant Cell Lines:  EPD0574_5_A08, EPD0574_5_B08, EPD0574_5_E08, EPD0574_5_H08
Germline Transmission:  Unknown
Parent Cell Line:  JM8A3.N1 (ES Cell)
Strain of Origin:  C57BL/6N-Atm1Brd
Project Collection: KOMP-CSD
Mutation
description
Allele Type:    Targeted (Null/knockout, Reporter)
Mutation:    Insertion     Vector: L1L2_Bact_P
 
Mutation detailsThe L1L2_Bact_P cassette was inserted at position 145938800 of Chromosome 5 upstream of the critical exon(s) (Build GRCm39). The cassette is composed of an FRT site followed by lacZ sequence and a loxP site. This first loxP site is followed by a neomycin resistance gene under the control of the human beta-actin promoter, SV40 polyA, a second FRT site and a second loxP site. Insertion of this cassette creates a reporter knockout mouse. Cre expression will remove the neomycin selection cassette. Further information on targeting strategies used for this and other IKMC alleles can be found at http://www.informatics.jax.org/mgihome/nomen/IKMC_schematics.shtml (J:148605, J:173534)
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 1 line available
Carrying any Cyp3a25 Mutation:  29 strains or lines available
References
Original:  J:148605 Wellcome Trust Sanger Institute, Alleles produced for the KOMP project by the Wellcome Trust Sanger Institute. MGI Direct Data Submission. 2009;
All:  2 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
11/28/2023
MGI 6.22
The Jackson Laboratory