Carm1tm2.1Mtb
Targeted Allele Detail
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Symbol: |
Carm1tm2.1Mtb |
Name: |
coactivator-associated arginine methyltransferase 1; targeted mutation 2.1, Mark T Bedford |
MGI ID: |
MGI:4454543 |
Synonyms: |
CARM1KI |
Gene: |
Carm1 Location: Chr9:21458163-21500763 bp, + strand Genetic Position: Chr9, Syntenic
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Alliance: |
Carm1tm2.1Mtb page
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Small size of Carm1tm2.1Mtb/Carm1tm2.1Mtb fetuses
Show the 1 phenotype image(s) involving this allele.
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Germline Transmission: |
Earliest citation of germline transmission:
J:159958
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Parent Cell Line: |
TC1/TC-1 (ES Cell)
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Strain of Origin: |
129S6/SvEvTac
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Allele Type: |
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Targeted |
Mutations: |
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Insertion, Nucleotide substitutions
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Mutation details: Nucleotide substitution in exon 3 results in the amino acid substitution of arginine to alanine at position 169 (R169A). Exons 2 and 3 are also floxed. Flp mediated recombination removed the neo cassette upstream of exon 2. The predicted product is expected to be kinase dead.
(J:159958)
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Generation of the knock-in Carm1tm2.1Mtb allele |
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View phenotypes and curated references for all genotypes (concatenated display).
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Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available
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Carrying any Carm1 Mutation: |
93 strains or lines available
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Original: |
J:159958 Kim D, et al., Enzymatic activity is required for the in vivo functions of CARM1. J Biol Chem. 2010 Jan 8;285(2):1147-52 |
All: |
1 reference(s) |
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