Del(4C4-C5)1Lap
Targeted Allele Detail
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Symbol: |
Del(4C4-C5)1Lap |
Name: |
deletion, Chr 4, Len A Pennacchio 1 |
MGI ID: |
MGI:4440552 |
Synonyms: |
ANRIL-, chr4delta70kb, Del1Lap |
Gene: |
Del(4C4-C5)1Lap Location: unknown Genetic Position: Chr4, Syntenic
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Germline Transmission: |
Earliest citation of germline transmission:
J:158126
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Parent Cell Line: |
W4 (ES Cell)
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Strain of Origin: |
129S6/SvEvTac
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Allele Type: |
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Targeted (Null/knockout) |
Mutations: |
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Insertion, Intergenic deletion, Intragenic deletion
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Del(4C4-C5)1Lap involves 1 genes/genome features (Gm12610)
View all
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Mutation details: Cre mediated recombination removed a floxed 70 kb region corresponding to the human 9p21 non-coding coronary artery disease risk interval. The 5' targeting vector contained a 5' homologous region and loxP site upstream of a neo cassette while the 3' targeting vector contained a copy of the 3' homologous region and hygro cassette upstream of a loxP site. Reduced expression of
Cdkn2a and Cdkn2b was confirmed by qRT-PCR on heart and other tissue extracts.
(J:158126)
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View phenotypes and curated references for all genotypes (concatenated display).
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Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
Carrying this Mutation: |
Mouse Strains: 1 strain available
Cell Lines: 0 lines available
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Carrying any Del(4C4-C5)1Lap Mutation: |
0 strains or lines available
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Original: |
J:158126 Visel A, et al., Targeted deletion of the 9p21 non-coding coronary artery disease risk interval in mice. Nature. 2010 Mar 18;464(7287):409-12 |
All: |
7 reference(s) |
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