Del(4C4-C5)1Lap Cytogenetic Marker Detail

Summary

• Symbol
  Del(4C4-C5)1Lap
• Name
  deletion, Chr 4, Len A Pennacchio 1
• Synonyms
  chr4^delta70kb, Del(4)1Lap

• Feature Type
  chromosomal deletion
• IDs
  MGI:4440590

Location &
Maps

• Sequence Map
  Genome coordinates not available from the current reference assembly.

• Genetic Map
  Chromosome 4, Syntenic

Mutations,
Alleles, and
Phenotypes

• Phenotype Summary
  19 phenotypes from 1 allele in 1 genetic background
  7 phenotype references
  

• All Mutations and Alleles
  1
• Targeted
  1
• Find Mice (IMSR)
  0 strains or lines available

Mice homozygous for this deletion exhibit prenatal and postnatal lethality and premature death associated with increased tumor incidence and abnormal aortic vascular smooth muscle cell physiology.

References

• Summaries
  All 8

  Phenotypes 7
• Earliest
  J:158126 Visel A, et al., Targeted deletion of the 9p21 non-coding coronary artery disease risk interval in mice. Nature. 2010 Mar 18;464(7287):409-12
• Latest
  J:345211 Kettunen S, et al., Deletion of the murine ortholog of human 9p21.3 locus promotes atherosclerosis by increasing macrophage proinflammatory activity. Front Cardiovasc Med. 2023;10:1113890