Dnm1l^tm1.1Miha
Targeted Allele Detail

Summary

• Symbol: Dnm1l^tm1.1Miha
• Name: dynamin 1-like; targeted mutation 1.1, Katsuyoshi Mihara
• MGI ID: MGI:4438630
• Synonyms: Drp1^lox
• Gene: Dnm1l Location: Chr16:16130094-16176823 bp, - strand Genetic Position: Chr16, 10.12 cM
• Alliance: Dnm1l^tm1.1Miha page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:158142
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: A loxP site was inserted upstream of exon 2 and a floxed neo cassette was inserted downstream of exon 2. Cre mediated recombination removed the neo cassette leaving exon 2 floxed. (J:158142)

Expression

In Structures Affected by this Mutation:

7 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Dnm1l Mutation: 43 strains or lines available

References

• Original: J:158142 Ishihara N, et al., Mitochondrial fission factor Drp1 is essential for embryonic development and synapse formation in mice. Nat Cell Biol. 2009 Aug;11(8):958-66
• All: 23 reference(s)