Gdf11^tm2.1Sjl
Targeted Allele Detail

Summary

• Symbol: Gdf11^tm2.1Sjl
• Name: growth differentiation factor 11; targeted mutation 2.1, Sejin Lee
• MGI ID: MGI:4438481
• Synonyms: Gdf11^flox
• Gene: Gdf11 Location: Chr10:128718164-128727587 bp, - strand Genetic Position: Chr10, 77.18 cM, cytoband D3
• Alliance: Gdf11^tm2.1Sjl page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:158173
• Parent Cell Line: MC1 (ES Cell)
• Strain of Origin: 129S6/SvEvTac

Mutation description

Allele Type: Targeted (Conditional ready, No functional change) Mutation: Insertion Mutation details: A loxP site was inserted upstream of exon 2 and a floxed neo cassette was inserted downstream of exon 3. Cre mediated recombination removed the neo cassette leaving exons 2 and 3 floxed. (J:158173)

Generation of the Gdf11^tm2.1Sjl and Gdf11^tm2.2Sjl alleles

Expression

In Mice Carrying this Mutation:

3 assay results

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Gdf11 Mutation: 11 strains or lines available

References

• Original: J:158173 McPherron AC, et al., Redundancy of myostatin and growth/differentiation factor 11 function. BMC Dev Biol. 2009;9:24
• All: 7 reference(s)