Tg(tetO-CUGBP1)3413Coop
Transgene Detail

Summary

• Symbol: Tg(tetO-CUGBP1)3413Coop
• Name: transgene insertion 3413, Thomas A Cooper
• MGI ID: MGI:4438033
• Synonyms: TRECUGBP1
• Transgene: Tg(tetO-CUGBP1)3413Coop Location: unknown
• Alliance: Tg(tetO-CUGBP1)3413Coop page

Transgene origin

• Strain of Origin: Not Specified

Transgene description

• Transgene Type: Transgenic (Humanized sequence, Inducible, Inserted expressed sequence)
• Inducer: doxycycline/tetracycline
• Mutation: Insertion
• Tg(tetO-CUGBP1)3413Coop expresses 1 gene
  Transgene expresses:
  

  Organism

  Expressed Gene

  Homolog in Mouse

  Note

  human

  CELF1 (10658)

  Celf1

  (MGI:1342295)

• Mutation details: The tetracycline-responsive element and minimal CMV promoter drives expression of the FLAG-tagged LYLQ isoform of the human cDNA preceded by a genomic fragment containing the untranslated exons 2 and 3 with intron 2 of Myh6 and followed by a bovine hormone polyadenylation site and 3' flanking genomic sequence. Three lines were created (including lines 3413 and 3481). Line 3413 exhibit a 4- to 8-fold induction of exogenous protein expression. (J:157646)

Disease models

Expression

In Structures Affected by this Mutation:

4 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available

References

• Original: J:157646 Koshelev M, et al., Heart-specific overexpression of CUGBP1 reproduces functional and molecular abnormalities of myotonic dystrophy type 1. Hum Mol Genet. 2010 Mar 15;19(6):1066-75
• All: 5 reference(s)