Cyp3a^{tm1109(CYP3A4,CYP3A7)Arte}
Targeted Allele Detail

Summary

• Symbol: Cyp3a^{tm1109(CYP3A4,CYP3A7)Arte}
• Name: cytochrome P450, family 3, subfamily a cluster; targeted mutation 1109, TaconicArtemis
• MGI ID: MGI:4414658
• Synonyms: Cyp3a^{tm1(CYP3A4-CYP3A7)Arte}, Del(5Cyp3a57-Cyp3a59)1Arte^{tm1(CYP3A4-CYP3A7)Arte}, Is(5CYP3A4-CYP3A7;Del5Cyp3a57-Cyp3a59)2Arte
• Gene: Cyp3a Location: unknown Genetic Position: Chr5, Syntenic

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:286122
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: C57BL/6NTac

Mutation description

• Allele Type: Targeted (Humanized sequence, Inserted expressed sequence)
• Mutation: Insertion
• Cyp3a^{tm1109(CYP3A4,CYP3A7)Arte} involves 25 genes/genome features (Cyp3a57, Gm2314, Gm42859 ...) View all
• Cyp3a^{tm1109(CYP3A4,CYP3A7)Arte} expresses 2 genes
  Knock-in expresses:
  

  Organism

  Expressed Gene

  Homolog in Mouse

  Note

  human

  CYP3A4 (1576)

  Cyp3a13

  (MGI:88610)

  human

  CYP3A7 (1551)

  Cyp3a13

  (MGI:88610)

  CYP3A4 and CYP3A7

• Mutation details: Recombinase-targeting of Cyp3a^tm1.1Arte inserted 125 kb of genomic human DNA comprising CYP3A4 and CYP3A7. (J:286122)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Cyp3a Mutation: 0 strains or lines available

References

• Original: J:286122 Henderson CJ, et al., An Extensively Humanized Mouse Model to Predict Pathways of Drug Disposition and Drug/Drug Interactions, and to Facilitate Design of Clinical Trials. Drug Metab Dispos. 2019 Jun;47(6):601-615
• All: 4 reference(s)