Steap3^tm1.1Atel
Targeted Allele Detail

Summary

• Symbol: Steap3^tm1.1Atel
• Name: STEAP family member 3; targeted mutation 1.1, Adam Telerman
• MGI ID: MGI:4398911
• Synonyms: TSAP6^-, Tsap6^del2-3, TSAP6 KO
• Gene: Steap3 Location: Chr1:120154137-120198810 bp, - strand Genetic Position: Chr1, 52.66 cM, cytoband E2
• Alliance: Steap3^tm1.1Atel page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:154356
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: C57BL/6

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A 46 bp polynucleotide containing a LoxP site was added 404bp upstream exon 2, and a neomycin resistance gene floxed by two LoxP sites was added 533bp downstream exon 3. Cre-mediated excision of exons 2-3 was achieved upon electroporation of a Cre-recombinase expression vector in the correctly targeted ES clones. Protein was undetected in homozygous mutant mice by Western blot analysis and Immnunohistological staining. (J:154356)

Expression

In Structures Affected by this Mutation:

4 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Steap3 Mutation: 65 strains or lines available

References

• Original: J:154356 Lespagnol A, et al., Exosome secretion, including the DNA damage-induced p53-dependent secretory pathway, is severely compromised in TSAP6/Steap3-null mice. Cell Death Differ. 2008 Nov;15(11):1723-33
• All: 1 reference(s)