Parva^tm1Ref
Targeted Allele Detail

Summary

• Symbol: Parva^tm1Ref
• Name: parvin, alpha; targeted mutation 1, Reinhard Fassler
• MGI ID: MGI:4368017
• Synonyms: alpha-pv^-
• Gene: Parva Location: Chr7:112027102-112190899 bp, + strand Genetic Position: Chr7, 58.76 cM
• Alliance: Parva^tm1Ref page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:154437
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Null/knockout, Reporter)
• Mutation: Insertion
• Mutation details: An IRES-lacZ gene and neo cassette were inserted into exon 2. The absence of protein expression was confirmed by western blot analysis on muscle cell extracts. (J:154437)

Expression

In Structures Affected by this Mutation:

7 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Parva Mutation: 27 strains or lines available

References

• Original: J:154437 Montanez E, et al., Alpha-parvin controls vascular mural cell recruitment to vessel wall by regulating RhoA/ROCK signalling. EMBO J. 2009 Oct 21;28(20):3132-44
• All: 2 reference(s)