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Targeted Allele Detail
Symbol: Ndrg3tm1a(KOMP)Wtsi
Name: N-myc downstream regulated gene 3; targeted mutation 1a, Wellcome Trust Sanger Institute
MGI ID: MGI:4362598
Gene: Ndrg3  Location: Chr2:156769265-156833976 bp, - strand  Genetic Position: Chr2, 77.89 cM
Alliance: Ndrg3tm1a(KOMP)Wtsi page
IMPC: Ndrg3 gene page
Mutant Cell Lines:  EPD0025_4_A01, EPD0025_4_A02, EPD0025_4_A03, EPD0025_4_B01, EPD0025_4_B02, EPD0025_4_B03, EPD0025_4_C01, EPD0025_4_C03, EPD0025_4_D01, EPD0025_4_D03, EPD0025_4_E02, EPD0025_4_F02, EPD0025_4_F03, EPD0025_4_G01, EPD0025_4_G02, EPD0025_4_G03, EPD0025_4_H01, EPD0025_4_H02, EPD0025_4_H03
Germline Transmission:  Earliest citation of germline transmission: J:204812
Parent Cell Line:  JM8.N4 (ES Cell)
Strain of Origin:  C57BL/6N
Project Collection: KOMP-CSD
Allele Type:    Targeted (Conditional ready, Null/knockout, Reporter)
Mutation:    Insertion     Vector: L1L2_gt0
Mutation detailsThe L1L2_gt0 cassette was inserted at position 156791669 of Chromosome 2 upstream of the critical exon(s) (Build GRCm39). The cassette is composed of an FRT flanked lacZ/neomycin sequence followed by a loxP site. An additional loxP site is inserted downstream of the targeted exon(s) at position 156792496. The critical exon(s) is/are thus flanked by loxP sites. A "conditional ready" (floxed) allele can be created by flp recombinase expression in mice carrying this allele. Subsequent cre expression results in a knockout mouse. If cre expression occurs without flp expression, a reporter knockout mouse will be created. Further information on targeting strategies used for this and other IKMC alleles can be found at http://www.informatics.jax.org/mgihome/nomen/IKMC_schematics.shtml (J:148605, J:173534)
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 1 line available
Carrying any Ndrg3 Mutation:  39 strains or lines available
Original:  J:148605 Wellcome Trust Sanger Institute, Alleles produced for the KOMP project by the Wellcome Trust Sanger Institute. MGI Direct Data Submission. 2009;
All:  4 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
MGI 6.22
The Jackson Laboratory